Libin Rong
时间:2015-01-23  浏览:1319次

演讲人:Libin Rong, Department of Mathematics and Statistics, Oakland University, Rochester, Michigan, USA



演讲摘要:Chronic hepatitis C virus (HCV) infection remains a public health problem worldwide. Traditional therapy leads to viral elimination in less than 50% of treated patients. New treatment using direct-acting antiviral agents (DAAs) has significantly increased the cure rate. These new DAA drugs directly interfere with different steps of the HCV life cycle. Thus, existing models that do not consider intracellular processes may not be optimal in analyzing data from patients treated with these drugs. In this talk, I will discuss recent advances in developing multi-scale mathematical models that can study HCV dynamics under therapy with new DAAs. The models include both intracellular viral replication and extracellular cell infection. I will address model analysis, approximation, comparison with experimental data, as well as the implications for developing new treatment strategies for hepatitis C.